Novel Therapeutics for Management of Lupus Nephritis: What Is Next?

Lupus Nephritis is a severe, organ-threatening manifestation of Systemic Erythematosus (SLE). The current standard care in the treatment lupus nephritis limited to broad-spectrum immunosuppressants, which have significant concerns short- and long-term toxicity. With traditional approaches, kidney survival patient outcomes remained suboptimal. Robust research therapeutics has resulted development many novel drugs targeting specific inflammatory response pathways. Some newer agents shown definitive signal benefit when added care. advent precision medicine nephrology, may undergo shift towards incorporating approaches using these individualizing our patients. This review highlights major advances management over last 25 years, explores ongoing trials emerging therapies nephritis.